Additional Benefits of Fucoidan
Anti- Coagulation
• Skin moisturizing Effect
• Prevention of Rise in Blood Pressure
• Improvement in Intestinal Environment
• Anti-Helicobacter Pylori Activity
• Anti-Ulcer Activity
• Enhancement of Hepatic Functions
• Relieving Effect on Allergic Activities (Hay Fever, Atrophy, etc.)
• Anti-HIV Activity
• Hair-Growth Effect
• Anti-Viral, Anti-Bacterial Activity
• Skin moisturizing Effect
• Prevention of Rise in Blood Pressure
• Improvement in Intestinal Environment
• Anti-Helicobacter Pylori Activity
• Anti-Ulcer Activity
• Enhancement of Hepatic Functions
• Relieving Effect on Allergic Activities (Hay Fever, Atrophy, etc.)
• Anti-HIV Activity
• Hair-Growth Effect
• Anti-Viral, Anti-Bacterial Activity
Upcoming Research Abstracts
- Cancer treatment support
- Pre and post Radiation treatment support
- Pre and post Chemotherapy treatment support
- Prevention and Recurrence
- Cancer types and stages (Grams recommended)
Sulfated polysaccharides from brown seaweeds Saccharina japonica and Undaria pinnatifida: isolation, structural characteristics, and antitumor activity
During the last decade brown seaweed attracted much attention as a source of polysaccharides, namely laminarans, algini acids, and sulfated polysaccharides—fucoidans, with various structures and biological activities. In this study, sulfated polysaccharides were isolated from brown seaweeds Saccharina japonica (formerly named Laminaria) and Undaria pinnatifida and their antitumor activity was tested against human breast cancer T-47D and melanoma SK-MEL-28 cell lines… Fucoidans from S. japonica and U. pinnatifida distinctly inhibited proliferation and colony formation in both breast cancer and melanoma cell lines in a dose-dependent manner. These results indicated that the use of sulfated polysaccharides from brown seaweeds S. japonica and U. pinnatifida might be a potential approach for cancer treatment.
During the last decade brown seaweed attracted much attention as a source of polysaccharides, namely laminarans, algini acids, and sulfated polysaccharides—fucoidans, with various structures and biological activities. In this study, sulfated polysaccharides were isolated from brown seaweeds Saccharina japonica (formerly named Laminaria) and Undaria pinnatifida and their antitumor activity was tested against human breast cancer T-47D and melanoma SK-MEL-28 cell lines… Fucoidans from S. japonica and U. pinnatifida distinctly inhibited proliferation and colony formation in both breast cancer and melanoma cell lines in a dose-dependent manner. These results indicated that the use of sulfated polysaccharides from brown seaweeds S. japonica and U. pinnatifida might be a potential approach for cancer treatment.
Immunostimulatory effects of fucoidan on bone marrow-derived dendritic cells
Fucoidan is a polysaccharide purified from the brown seaweed Fucus vesiculosus. Although some effects of fucoidan on immune functions have been elucidated, there have been no studies concerning the immunomodulatory effects of fucoidan on dendritic cells (DCs), which are powerful antigen-presenting cells… Taken together, the results suggest that fucoidan has immunostimulating and maturing effects on DCs, via a pathway involving at least NF-kB.
Fucoidan is a polysaccharide purified from the brown seaweed Fucus vesiculosus. Although some effects of fucoidan on immune functions have been elucidated, there have been no studies concerning the immunomodulatory effects of fucoidan on dendritic cells (DCs), which are powerful antigen-presenting cells… Taken together, the results suggest that fucoidan has immunostimulating and maturing effects on DCs, via a pathway involving at least NF-kB.
Anti-HIV Activity of Extracts and Compounds from Algae and Cyanobacteria
The human immunodeficiency virus (HIV) is the retrovirus that causes the acquired immune deficiency disease syndrome (AIDS). This review discusses the anti-HIV activity of extracts and compounds isolated from freshwater and marine algae, and cyanobacteria. Compounds and extracts with anti-HIV activity are also active against other retroviruses such as herpes simplex virus (HSV), but the amount of antiviral activity varies with the compound and virus. Most of the research has focused on sulfated homopolysaccharides and heteroplysaccharides. Sulfoglycolipids, carrageenans, fucoidan, sesquiterpene hydroquinones, and other classes of compounds with anti-HIV activity that have been isolated from algae have received less attention. Most studies have used in vitro test systems, but a few in vivo studies have been carried out using compounds isolated from algae or analogs produced synthetically or isolated from other natural sources. Sulfated homopolysaccharides are more potent than sulfated heteropolysaccharides. The presence of the sulfate group is necessary for anti-HIV activity, and potency increases with the degree of sulfation. Studies using nonsulfated and sulfated homo- and heteropolysaccharides isolated from algae or other natural sources, or synthesized, have revealed the mechanisms of viral binding to host cells. However, given the few classes of compounds in algae and cyanobacteria with antiretroviral activity is probably not known.
The human immunodeficiency virus (HIV) is the retrovirus that causes the acquired immune deficiency disease syndrome (AIDS). This review discusses the anti-HIV activity of extracts and compounds isolated from freshwater and marine algae, and cyanobacteria. Compounds and extracts with anti-HIV activity are also active against other retroviruses such as herpes simplex virus (HSV), but the amount of antiviral activity varies with the compound and virus. Most of the research has focused on sulfated homopolysaccharides and heteroplysaccharides. Sulfoglycolipids, carrageenans, fucoidan, sesquiterpene hydroquinones, and other classes of compounds with anti-HIV activity that have been isolated from algae have received less attention. Most studies have used in vitro test systems, but a few in vivo studies have been carried out using compounds isolated from algae or analogs produced synthetically or isolated from other natural sources. Sulfated homopolysaccharides are more potent than sulfated heteropolysaccharides. The presence of the sulfate group is necessary for anti-HIV activity, and potency increases with the degree of sulfation. Studies using nonsulfated and sulfated homo- and heteropolysaccharides isolated from algae or other natural sources, or synthesized, have revealed the mechanisms of viral binding to host cells. However, given the few classes of compounds in algae and cyanobacteria with antiretroviral activity is probably not known.
Marine compounds and their antiviral activities
Available treatments for many infectious diseases are limited. In particular, diseases caused by viral pathogens have demonstrated the need for new medicines, due to the increasing appearance of resistance to these available treatments. Thousands of novel compounds have been isolated from various marine organisms and tested for pharmacological properties, many of which are commercially available. The screening of natural products derived from marine species for antiviral activity has yielded a considerable number of active crude aqueous and organic solvent extracts. Today, over 40 compounds are commercially available in pharmacological markets, including alternative antiviral medicines or those being tested as potential antiviral drugs. Many more are being tested as potential antiviral drugs at the preclinical and clinical stages. The growing interest in marine-derived antiviral compounds, along with the development of new technology in marine cultures and extraction, will significantly expedite the current exploration of the marine environment for compounds with significant pharmacological applications, which will continue to be a promising strategy and new trend for modern medicine.
Available treatments for many infectious diseases are limited. In particular, diseases caused by viral pathogens have demonstrated the need for new medicines, due to the increasing appearance of resistance to these available treatments. Thousands of novel compounds have been isolated from various marine organisms and tested for pharmacological properties, many of which are commercially available. The screening of natural products derived from marine species for antiviral activity has yielded a considerable number of active crude aqueous and organic solvent extracts. Today, over 40 compounds are commercially available in pharmacological markets, including alternative antiviral medicines or those being tested as potential antiviral drugs. Many more are being tested as potential antiviral drugs at the preclinical and clinical stages. The growing interest in marine-derived antiviral compounds, along with the development of new technology in marine cultures and extraction, will significantly expedite the current exploration of the marine environment for compounds with significant pharmacological applications, which will continue to be a promising strategy and new trend for modern medicine.
Anticancer drugs from marine flora
Marine floras, such as bacteria, actinobacteria, cyanobacteria, fungi, microalgae, seaweeds, mangroves, and other halophytes are extremely important oceanic resources, constituting over 90% of the biomass. They are taxonomically diverse, largely productive, biologically active, and chemically unique offering a great scope for discovery of a new anticancer drugs. The marine floras are rich in medicinally potent chemicals predominantly belonging to polyphenols and sulfated polysaccharides. The chemicals have displayed an array of pharmacological properties especially antioxidant, immunostimulatory, and antitumor activities. The phytochemicals possibly activate macrophages, induce apoptosis, and prevent oxidative damage of DNA, thereby controlling carcinogenesis. In spite of vast resources enriched with chemicals, the marine floras are largely unexplored for anticancer lead compounds. Hence, this paper reviews the works so far conducted on this aspect with a view to provide a baseline information for promoting the marine flora-based anticancer research in the present context of increasing cancer incidence, deprived of the cheaper, safer, and potent medicines to challenge the dreadful human disease.
Marine floras, such as bacteria, actinobacteria, cyanobacteria, fungi, microalgae, seaweeds, mangroves, and other halophytes are extremely important oceanic resources, constituting over 90% of the biomass. They are taxonomically diverse, largely productive, biologically active, and chemically unique offering a great scope for discovery of a new anticancer drugs. The marine floras are rich in medicinally potent chemicals predominantly belonging to polyphenols and sulfated polysaccharides. The chemicals have displayed an array of pharmacological properties especially antioxidant, immunostimulatory, and antitumor activities. The phytochemicals possibly activate macrophages, induce apoptosis, and prevent oxidative damage of DNA, thereby controlling carcinogenesis. In spite of vast resources enriched with chemicals, the marine floras are largely unexplored for anticancer lead compounds. Hence, this paper reviews the works so far conducted on this aspect with a view to provide a baseline information for promoting the marine flora-based anticancer research in the present context of increasing cancer incidence, deprived of the cheaper, safer, and potent medicines to challenge the dreadful human disease.
Fucoidan Inhibits Lewis Lung Carcinoma Cells Migration
Cancer is one of the leading causes of death in the world. It has been estimated that more than two-thirds of human cancers could be prevented by modification of lifestyle including dietary modification. For example, the consumption of fucoidan has been associated with reduced risk of several types of cancers. The biological effects of fucoidan, such as anti-oxidant, anti-tumor, immmunomodulatory, anti-complement, blood lipids redicing and anti-virus. However, the effects of fucoidan in anti-migration of tumor cells have not been studied. In this study, we find that fucoidan significantly induced the expression of white blood cells and anti-tumor immunity and could act as a strong immunomodulator. On the part of metastasis, increase expression of MMPs and VEGF were observed in a mouse lung carcinoma model, and these were blocked by fuocidan. Significant impairs migration were further demonstrated in vitro by treating with fucoidan though suppression of MMPs activity in Lewis Lung carcinoma cells. Overall, these findings implicated that fucoidan is a novel, effective, anti-migration agent for the treatment of migratory lung cancer risk.
Cancer is one of the leading causes of death in the world. It has been estimated that more than two-thirds of human cancers could be prevented by modification of lifestyle including dietary modification. For example, the consumption of fucoidan has been associated with reduced risk of several types of cancers. The biological effects of fucoidan, such as anti-oxidant, anti-tumor, immmunomodulatory, anti-complement, blood lipids redicing and anti-virus. However, the effects of fucoidan in anti-migration of tumor cells have not been studied. In this study, we find that fucoidan significantly induced the expression of white blood cells and anti-tumor immunity and could act as a strong immunomodulator. On the part of metastasis, increase expression of MMPs and VEGF were observed in a mouse lung carcinoma model, and these were blocked by fuocidan. Significant impairs migration were further demonstrated in vitro by treating with fucoidan though suppression of MMPs activity in Lewis Lung carcinoma cells. Overall, these findings implicated that fucoidan is a novel, effective, anti-migration agent for the treatment of migratory lung cancer risk.
Effect of fucoidan on fibroblast growth factor-2-induced angiogenesis in vitro
Fucoidans are sulfated polysaccharides extracted from brown marine algae. A purified fucoidan fraction exhibits the same venous antithrombotic activity as heparin in rabbits, but with lower anticoagulant effect. Because of its heparin-like structure, we postulated that fucoidan might modulate heparin-binding angiogenic growth factor activity… These results show that, at antithrombotic concentrations, contrary to heparin, fucoidan can enhance vascular tube formation induced by FGF-2 with a modulation of the expression of surface proteins involved in angiogenesis.
Fucoidans are sulfated polysaccharides extracted from brown marine algae. A purified fucoidan fraction exhibits the same venous antithrombotic activity as heparin in rabbits, but with lower anticoagulant effect. Because of its heparin-like structure, we postulated that fucoidan might modulate heparin-binding angiogenic growth factor activity… These results show that, at antithrombotic concentrations, contrary to heparin, fucoidan can enhance vascular tube formation induced by FGF-2 with a modulation of the expression of surface proteins involved in angiogenesis.
Anticancer activity in vitro of a fucoidan from the brown algae.
Fucoidan was isolated and purified from the brown algae Fucus evanescens and subjected to autohydrolysis to obtain low-molecular-weight fragments. MALDI-TOFMS analysis has shown that monosulfated fucose and more heavily sulfated (up to 5) fucooligosacchararides with polymerization degree (DP) 2, 4 and 6, including galactose-containing sulfated oligosaccharides were the products of autohydrolysis.
Fucoidan was isolated and purified from the brown algae Fucus evanescens and subjected to autohydrolysis to obtain low-molecular-weight fragments. MALDI-TOFMS analysis has shown that monosulfated fucose and more heavily sulfated (up to 5) fucooligosacchararides with polymerization degree (DP) 2, 4 and 6, including galactose-containing sulfated oligosaccharides were the products of autohydrolysis.
Health Benefits of FucoidanScientific studies have been conducted extensively on Fucoidan’s health benefits, unique biological properties and mechanisms to treat a wide range of health conditions in vitro and in vivo such as: colds and flu, hepatitis, anticoagulant, diabetes, cardiovascular diseases, antiviral (herpes & HIV), immunomodulating, antitumor and cancer.
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